Overview of IGF-1 LR3

IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a recombinant analogue of human IGF-1 with two key modifications: a 13-amino-acid extension at the N-terminus and substitution of arginine for glutamic acid at position 3. These changes dramatically reduce binding to IGF-binding proteins (IGFBPs), resulting in approximately 3x greater bioactivity and a dramatically extended half-life from minutes to ~20-30 hours.

Each vial available from SteroidsCanada.ca contains 1mg of lyophilized IGF-1 LR3, manufactured to rigorous pharmaceutical-grade standards and independently verified for purity exceeding 98% via HPLC analysis. This makes it an ideal choice for qualified researchers and laboratory professionals seeking dependable, high-quality peptides for growth factor peptide research applications.

Mechanism of Action

IGF-1 LR3 binds to IGF-1 receptors throughout the body, activating the PI3K/Akt and MAPK signaling pathways. These pathways regulate cell growth, differentiation, protein synthesis, and glucose uptake. The LR3 modifications allow sustained receptor activation far beyond what native IGF-1 can achieve, making it a powerful research tool for studying IGF-1 pathway activation.

Key Research Applications

Product Specifications

Reconstitution Guidelines

IGF-1 LR3 is supplied as a lyophilized (freeze-dried) powder that must be reconstituted with sterile bacteriostatic water (0.9% benzyl alcohol) before use in research applications. The recommended reconstitution volume for this vial is 1mL of bacteriostatic water, which yields a concentration suitable for precise research dosing.

Reconstitution Math — Quick Reference

If you add 1mL of bacteriostatic water to this 1mg vial:

On a standard 100 IU insulin syringe, here’s what each measurement equals for research reference:

Reconstitution Best Practices

• Use sterile bacteriostatic water (0.9% benzyl alcohol preservative)
• Add diluent slowly along the vial wall — never directly onto the peptide cake
• Gently swirl to dissolve — never shake the vial vigorously
• Allow the peptide to fully dissolve before drawing any dose
• Store reconstituted vials at 2–8°C (refrigerator)
• Use reconstituted peptide within 28–60 days depending on specific research requirements
• Always use sterile technique when drawing from the reconstituted vial

Research Protocol Guidelines

Research protocols commonly use 50-100mcg daily, typically administered post-exercise in muscle research models for localized effects.

Typical Research Timeline

• Week 1-2: Initial IGF-1R pathway activation
• Week 3-4: Peak satellite cell research effects
• Week 5-6: End of typical 4-6 week research cycles
• Week 7-8: Wash-out phase in research protocols

Individual research results vary based on protocol design, specific research objectives, and research model characteristics. The above timeline represents commonly observed patterns in published research literature.

Research Stacking Protocols

In research applications, IGF-1 LR3 is often studied in combination with complementary research peptides to investigate pathway interactions. Common research combinations include:

• IGF-1 LR3 + CJC-1295/Ipamorelin: Complete GH/IGF-1 axis
• IGF-1 LR3 + BPC-157: Muscle + tissue repair research
• IGF-1 LR3 + TB-500: Regenerative research combination

Any research stacking protocol should be designed based on specific investigative objectives and informed by current scientific literature.

Why Choose SteroidsCanada.ca?

• ✅ Pharmaceutical-grade IGF-1 LR3 — lab tested for purity and potency
• ✅ Discreet shipping across Canada — plain outer packaging always
• ✅ Proper cold-chain handling to preserve peptide integrity
• ✅ Same-day dispatch on orders placed before 2PM EST
• ✅ COA available on request for every batch and SKU
• ✅ Secure payment — Interac E-Transfer and cryptocurrency
• ✅ Free shipping on all orders over $600 CAD
• ✅ Competitive Canadian pricing with no hidden fees
• ✅ Responsive customer service and reliable restocking