Robert F.Verified buyer
Reply from SteroidsCanada
We really appreciate the five stars, Robert! Thanks for trusting us with your SM5 order.
SM5
5.007 reviewsPER BOTTLE$150CAD
$30.00 per mg
$30.00 per mg
SM5: Semaglutide, 5 mg per vial, 1 vial. Ships from inside Canada in plain packaging, with tracking within 72 hours; free Canada Post shipping over $300.
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Ships from inside CanadaTracking in 72 h
Canada Post Xpresspost$30Free over $300
UPS or FedEx$60Free over $1,000
Plain box, tracked · Interac e-Transfer · card or Google Pay after your first order
- Compound
- Semaglutide
- Strength
- 5 mg per vial
- Pack
- 1 vial
- Total per order
- 5 mg
- Half-life
- About 7 days
- Form
- Freeze-dried powder
About SM5
SM5 contains semaglutide, a once-weekly GLP-1 medicine used for type 2 diabetes and weight management. It comes as freeze-dried powder to mix with bacteriostatic water.
Each order is one vial holding 5 mg of freeze-dried powder. Mix it with bacteriostatic water before use.
Commonly used for
- Weight loss
- Blood sugar control in type 2 diabetes
Compound profile
Semaglutide
- Formula
- C187H291N45O59
- Molecular weight
- 4,114 g/mol
- CAS number
- 910463-68-2
- PubChem
- CID 56843331
How it works
It acts like GLP-1, a gut hormone: it reduces appetite, slows stomach emptying and helps insulin release when blood sugar is high. Its half-life is about a week.
Half-life: about 7 days.
Release profile
How levels rise and fall after a single dose, based on a half-life of about 7 days. Each mark on the axis is one half-life; after about five, almost none is left.
An illustration from the half-life only; real levels vary with dose, how it is given and the person.
Clinical reference dose
Clinical reference: Health Canada-approved weight-management labelling starts at 0.25 mg once a week for 4 weeks, then steps up every 4 weeks (0.5, 1, 1.7 mg) to a maintenance dose of 2.4 mg a week. Diabetes labelling tops out at 2 mg a week.
0.25 mg0.1 ml = 10 units
0.5 mg0.2 ml = 20 units
Mixing: adding 2 ml of bacteriostatic water to this 5 mg vial gives 2.5 mg per ml. On a U-100 insulin syringe, 10 units (0.1 ml) then holds 0.25 mg.
Going up too fast is the main cause of nausea and vomiting.
These are reference amounts from labels and clinical studies, not a personal recommendation. A doctor sets the right dose for you, using your bloodwork.
Measuring calculator
Enter the amount you have been prescribed or are working from, and this works out exactly what to measure from this product. It doesn’t suggest an amount.
Measure—Enter an amount
- —
- —
Arithmetic only, from the strength on this product’s label. Check the label on your vial or bottle, follow your prescriber, and ask a pharmacist if you’re unsure how to measure.
Injection sites
SM5 comes as a freeze-dried powder. Once it is mixed with bacteriostatic water, peptides like this are usually given subcutaneously (subQ): into the fat just under the skin with a short insulin needle, not into muscle.
- Muscle
- Subcutaneous fat of the belly
- Group
- Abdominal wall
- Volume (nursing reference)
- Up to about 1 ml per site
- Needle
- 4–13 mm insulin needle, 29–31G
Finding it. Anywhere on the belly at least 5 cm (2 in) from the navel, avoiding scars, stretch marks and the belt line. Pinch a fold of skin and inject into the fold.
Why people choose it. The most-used subcutaneous site: the most fat, easy to see and reach, and absorption is steady. It is the first site listed on the labels of weekly GLP-1 pens.
Watch out. Move each injection at least 2–3 cm from the last one to avoid lumps (lipohypertrophy).
- Muscle
- Subcutaneous fat of the thigh
- Group
- Thigh
- Volume (nursing reference)
- Up to about 1 ml per site
- Needle
- 4–13 mm insulin needle, 29–31G
Finding it. The middle of the front of the thigh, a hand-width below the hip and above the knee.
Why people choose it. Easy to reach seated and a good second site to rotate with the belly.
Watch out. Absorption can be a little slower than the belly, and heavy leg exercise straight after may speed it up.
- Muscle
- Subcutaneous fat over the triceps
- Group
- Upper arm
- Volume (nursing reference)
- Up to about 1 ml per site
- Needle
- 4–13 mm insulin needle, 29–31G
Finding it. The fleshy back of the upper arm, halfway between the shoulder and the elbow.
Why people choose it. Adds a third site to rotate through, so each spot gets more rest.
Watch out. Hard to pinch and reach on yourself; most people need a helper here.
Why these sites for SM5
Subcutaneous (subQ)- Same three sites as the pens. Weekly medicines in this class are labelled for the abdomen, thigh or upper arm. Pick one area and move to a new spot each week.
- Belly first. The abdomen has the most fat and the steadiest absorption, and you can see what you are doing. The thigh and back of the arm are there to rotate into.
- Small volumes, short needle. SubQ injections are small (around 1 ml or less per spot). An insulin syringe (4–13 mm) reaches the fat without touching muscle; pinch the skin if you are lean.
- Rotate every time. Move each injection 2–3 cm from the last. Repeating one spot causes hard lumps under the skin that absorb unevenly.
Every time: wash your hands, wipe the vial top and the skin with alcohol and let it dry, use a new sterile needle and syringe, and never share. Get medical help for spreading redness, heat, swelling, pus, fever, numbness or pain that keeps getting worse. This is general reference information from standard nursing injection guidance, not medical advice; a pharmacist or nurse can show you the technique in person.
Compare brands
Same compound, different makers. Compare the strength, pack and cost per unit.
| Product | Strength | Pack | Price | Value | Buy |
|---|---|---|---|---|---|
 SM5You are here | 5 mg per vial | 1 vial | $150 | $30.00 per mg | |
 Vita SM10 10mg | 10 mg per vial | 1 vial | $180 | $18.00 per mg | Add |
 Vita SM5 5mg | 5 mg per vial | 1 vial | $144 | $28.80 per mg | Sold out |
Combinations and interactions
Often compared or used with
- Compared with TZ5, which acts on GIP as well as GLP-1, and Reta, which adds glucagon.
- Never combine two GLP-1-type medicines.
- Keep protein high and keep strength training to protect muscle during weight loss.
Interactions to know
- Insulin and sulfonylureas: risk of low blood sugar; doses usually drop.
- Oral medicines: slowed stomach emptying can change how they absorb.
- Alcohol: more nausea and low-sugar risk.
Tell your doctor and pharmacist about everything you take, including supplements, before adding anything new.
Side effects and risks
Stomach effects
Nausea, vomiting, diarrhea and constipation, worst after each dose increase.
Pancreatitis
Severe ongoing belly pain, sometimes into the back: go to emergency.
Gallbladder
Higher gallstone risk with fast weight loss.
Thyroid warning
Thyroid C-cell tumours occurred in rodents; the human risk is unknown.
Injection safety
Use a new sterile needle and syringe every time, wipe the stopper and skin with alcohol, and never share. Redness, heat or swelling that gets worse after a day or two can mean infection and needs a doctor.
Don’t use it if you
You or a family member have had medullary thyroid cancer or MEN 2, you have had pancreatitis, have type 1 diabetes, or are pregnant, breastfeeding or planning pregnancy.
In Canada: Semaglutide is a prescription drug in Canada. Talk to a doctor or pharmacist about whether it is right for you.
Bloodwork checklist
- A1C and fasting glucose
- Kidney function (creatinine, eGFR)
- Liver panel and lipids
- Lipase if you get belly pain
- Weight and blood pressure at home
Your family doctor can order these, or you can pay for private testing at labs such as LifeLabs or Dynacare. Retest about every 3 months.
Common questions
How do I store it?
Unmixed: cool and dark. Mixed: in the fridge (2–8 °C), never frozen.
What if I miss a dose?
Labels say take it within 5 days; otherwise skip and resume on your usual day.
How fast does it ship?
Orders ship from inside Canada with a tracking number within 72 hours of payment. Weekend orders are packed on Sunday or Monday. Canada Post Xpresspost takes 2–5 business days to most cities; UPS or FedEx is faster. Shipping is free by Canada Post over $300 and by UPS or FedEx over $1,000.
How is it packaged?
In a plain box with no product names or branding on the outside.
Is semaglutide legal in Canada?
Semaglutide is a prescription drug in Canada. Talk to a doctor or pharmacist about whether it is right for you.
Sources
- Once-Weekly Semaglutide in Adults with Overweight or ObesityWilding JPH et al. · N Engl J Med · 2021 · PMID 33567185
- Safety of SemaglutideSmits MM, Van Raalte DH · Front Endocrinol (Lausanne) · 2021 · PMID 34305810
- Acute pancreatitis due to different semaglutide regimens: An updated meta-analysisMasson W et al. · Endocrinol Diabetes Nutr (Engl Ed) · 2024 · PMID 38555109
Chemical data and structures: PubChem, U.S. National Library of Medicine. Protein sequences: UniProt.
Specifications
| Compound | Semaglutide |
|---|---|
| Strength | 5 mg per vial |
| Pack | 1 vial |
| Total per order | 5 mg |
| Half-life | About 7 days |
| Form | Freeze-dried powder |
| SKU | Sm5 |
Reviews
5.007 rated reviews
5★7
4★0
3★0
2★0
1★0
“Great product! Ordering was easy and delivery was fast. Will absolutely order products from this site again!”
Enrique R.Verified buyer
Reply from SteroidsCanada
Thank you for the 5-star rating, Enrique! We hope you're happy with your SM5, and we look forward to your next order.
AnonymousVerified buyer
Fast delivery.
Reply from SteroidsCanada
Thanks for the great review! Happy to hear delivery was fast. Thanks for choosing SteroidsCanada.ca.
MarekVerified buyer
So far so good. No complaints. I was worried it might be under dosed but it's not. Good stuff. Great seller. Fast delivery.
Reply from SteroidsCanada
Thanks for the great review, Marek! We're glad your order arrived quickly. We're glad we could take good care of you. Thanks for shopping with us.
Enrique R.Verified buyer
Reply from SteroidsCanada
Thanks so much for the rating, Enrique! It means a lot to our small Canadian team. See you next time.
SusanVerified buyer
Great product! Ordering was easy and delivery was fast. Will absolutely order products from this site again!
Reply from SteroidsCanada
Thank you for the kind words, Susan! We're glad your order arrived quickly. Thanks for being a loyal customer, it means a lot. Thanks for shopping with us.
Reviews come from verified buyers only. After your order arrives we email you a link to review it.
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This information is educational and is not medical advice. Talk to a doctor or pharmacist before using any hormone, peptide or prescription drug. For adults 18+ only.